The Board of Directors, OKI's policy making body, are elected and appointed representatives from county, township, and municipal governments in eight counties in greater Cincinnati, northern Kentucky, and southeast Indiana. Representatives from twelve city and county planning commissions, two state departments of transportation, and interested citizens are also represented on the OKI Board.

The Board of Directors is supported by a variety of advisory committees. These committees develop and review the technical aspects of transportation and environmental concerns and report their findings to the OKI Executive Committee, a core member group selected from the ranks of and by the full Board of Directors. The Executive Committee has the authority to make all policy decisions for the OKI Board.